leptomycin b造句

例句与造句

1. Leptomycin B ( LMB ) was originally discovered as a potent anti-fungal antibiotic.
2. Leptomycin B was found to cause cell elongation of the fission yeast " Schizosaccharomyces pombe ".
3. In addition to antifungal and antibacterial activities, leptomycin B blocks the cell cycle and is a potent anti-tumor agent.
4. This process is also energy dependent as it consumes one GTP . Export with the exportin CRM1 can be inhibited by Leptomycin B.
5. The export mediated by CRM1 can be effectively inhibited by the fungicide leptomycin B ( LMB ), providing excellent experimental veri
   鹀ation of this pathway.
6. It's difficult to find leptomycin b in a sentence. 用leptomycin b造句挺难的
7. Aside from sharing the same absolute stereochemistry as leptomycin B, callystatin A was discovered to have similar biological activity with leptomycin B as well.
8. Aside from sharing the same absolute stereochemistry as leptomycin B, callystatin A was discovered to have similar biological activity with leptomycin B as well.
9. Leptomycin B has been shown to be a potent and specific nuclear export inhibitor in human and the fission yeast " S . pombe ".
10. Leptomycin B also inhibits the export and translation of many RNAs, including COX-2 and c-Fos mRNAs, by inhibiting export of ribonucleoproteins.
11. The most important role of leptomycin B is its inhibitory effect on the NES-dependent nuclear export mechanism, leading to the cell cycle arrest during G1 and G2 phases in eukaryotic cells.
12. Leptomycin B ( LMB ) binds to CRM1 which prevents the formation of the complex required for export ( CRM1 / NES / RanGTP / RRE ) and ultimately reduces the production of incompletely spliced RNAs.
13. At low nM concentrations, leptomycin B blocks the nuclear export of many proteins including HIV-1 Rev, MAPK / ERK, and NF-?B / I?B, and it inhibits the inactivation of p53.
14. The anti-tumor activity of leptomycin B and callystatin A arises because many NES-cargo molecules blocked by these antibiotics are those involved in the cellular processes of proliferation, differentiation, and development, learning and memory, and hormone action.
15. Leptomycin B alkylates and inhibits " CRM1 " ( chromosomal region maintenance ) / exportin 1 ( ), a protein required for nuclear export of proteins containing a nuclear export sequence ( NES ), by glycosylating a cysteine residue ( cysteine 529 in " S . pombe " ).